Proteomic Screening of Glycoproteins in Human Plasma for Frailty Biomarkers
نویسندگان
چکیده
منابع مشابه
Glycoproteomic Analysis of Human Plasma for Frailty Biomarkers
1 FRAILTY, an age-related syndrome, is an important clinical and public health problem present in 10 % – 15% of adults over the age of 65 years in the U nited S tates and is marked by progressive physical decline, medical comorbidity, disability, and mortality ( 1 ) . Frailty is hypothesized to be a phenotype of accelerated aging and has been associated with changes in several physiologic al sy...
متن کاملPlasma protein biomarkers of the geriatric syndrome of frailty.
Frailty is a geriatric syndrome associated with physical decline with aging. Using a proteomics-based screening method to screen plasma for potential biomarkers, we previously found inflammatory glycoproteins to be increased with frailty. The purpose of this study was to confirm if plasma levels of these glycoproteins, as well as of interleukin-6, are increased with frailty in a larger sample (...
متن کاملQuantitative proteomic analysis for high-throughput screening of differential glycoproteins in hepatocellular carcinoma serum
OBJECTIVE Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths. Novel serum biomarkers are required to increase the sensitivity and specificity of serum screening for early HCC diagnosis. This study employed a quantitative proteomic strategy to analyze the differential expression of serum glycoproteins between HCC and normal control serum samples. METHODS Lectin affinity...
متن کاملProteomic biomarkers for autoimmune disease.
Autoimmune diseases affect 3% of the world population, yet the diagnosis and classification of autoimmune diseases remain based on clinical examination combined with traditional laboratory tests and imaging studies. The development of genomic and proteomic technologies provides an unprecedented ability to identify novel biosignatures to diagnose, classify, and guide therapeutic decision making ...
متن کاملProteomic Biomarkers of Atherosclerosis
SUMMARY: Biomarkers provide a powerful approach to understanding the spectrum of cardiovascular diseases. They have application in screening, diagnostic, prognostication, prediction of recurrences and monitoring of therapy. The "omics" tool are becoming very useful in the development of new biomarkers in cardiovascular diseases. Among them, proteomics is especially fitted to look for new protei...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journals of Gerontology: Series A
سال: 2012
ISSN: 1758-535X,1079-5006
DOI: 10.1093/gerona/glr224